Because the BBEG has been in that castle a little too long.

Some poisons also require expensive materials to create to be granted their potent effect.

This could cause the Dungeon Master to send their party on a side quest to obtain said materials.

Dungeons & Dragons split image of a rogue on a rooftop and an assassin sneaking behind a guard

You will also learn that each poison has different methods of app.

The official Dungeons & Dragons source materialcontains fourteen different poisons.

Depending on the key in, they all cost between a couple of hundred gold and a few thousand.

Dungeons & Dragons image showing adventurers nearing the raven queen castle

Keys from the Golden Vault art by Evyn Fong

Poisoned Condition for 24 Hours.

Burnt Othur Fumes (500gp)

Inhaled

3d6 Poison Damage.

Lingering 1d6 Poison Damage.

Poison by Ed Cox on a canvas background

Carrion Crawler Mucus (200gp)

Contact

Poisoned Condition for 1 Minute.

Drow Poison (200gp)

Injury

Poisoned Condition for 1 Hour.

Unconscious if failed save by 5 or more.

Split image of different characters using poison

Essence Of Ether (300gp)

Poisoned Condition for 8 Hours.

Malice (250gp)

Poisoned Condition for 1 Hour.

Midnight Tears (1,500gp)

9d6 Poison Damage at Midnight.

Dungeons & Dragons Keys from the Golden Vault art by Evyn Fong showing two characters hold guards hostage while another steals a treasure.

Keys from the Golden Vault art by Evyn Fong

Oil Of Taggit (400gp)

Poisoned Condition for 24 Hours.

Pale Tincture (250gp)

1d6 Poison Damage every 24 Hours.

Cant be healed until succeeding 7 Saving Throws.

Qunbraxel, Leader Of The Grimlocks In Gibbet Crossing, Sits On A Throne.

Purple Worm Poison (2,000gp)

12d6 Poison Damage.

Serpent Venom (200gp)

3d6 Poison Damage.

Torpor (600gp)

Poisoned Condition for 4d6 Hours.

Tabletop

Truth Serum (150gp)

Poisoned Condition for 1 Hour.

Under conditions of the Zone of Truth spell while Poisoned.

Wyvern Poison (1,200gp)

7d6 Poison Damage.

d&d

Injury Poisons will have their effect wear off after a successful hit.

They must also be applied/intentionally wiped off to use or remove it.

Dungeon Masters enjoy using poisons as story elements.

The most common bang out of poison is Injury-based (coating a weapon with poison).

Remember towait until you need it to apply the poison.

Otherwise, it willlose effect after a minuteor be wiped away.

However,Ingested poisons often have the strongest effects, so the payoff is worth it.

Learn how to roleplay the sinister Mind Flayers as a DM in D&D!